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Across those human studies, the effects on body weight and fat mass are usually modest and depend on dose, form, and how L-carnitine is used alongside diet and training

N Engl J Med 376:890

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Angiotensin II receptors and drug discovery in cardiovascular disease

Anti-obesity drug therapy can be offered as an adjunct to a reduced-calorie diet and increased physical activity for weight management in adult patients with an initial body mass index (BMI) of 30 kg/m 2 or 2730 kg/m 2 in the presence of at least one weight-related comorbidity, e.g., dysglycemia, hypertension, dyslipidemia, or obstructive sleep apnea

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