JAMA, 331 (1), 3848.
Quality verification becomes even more important when combining compounds, since impurities or inaccurate dosing in one product amplify risks when another compound is added to the protocol
Energy levels: Some people experience a noticeable increase in energy on tirzepatide, potentially related to improved glucose metabolism and the effects of GIP receptor activation
It's a completely different class of molecule
To restate the point clearly: a high serum B12 level is not, by itself, what's making you feel anxious or giving you palpitations
In addition, various scenario analyses were performed to evaluate the robustness of the results of the cost-effectiveness model and to explore the impact of different assumptions on the estimates, including alternative time horizons, longer maximum treatment durations, analysis of a cohort of patients without T2DM, an alternative initial proportion of women, gradual restoration of the values of surrogate variables after treatment according to natural progression, changes in mortality considered, exclusion of treatment discontinuation, exclusion of bariatric surgery as a potential subsequent treatment option, and use of the efficacy of the trial product estimand (Tables S18 and S19)
