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Even though physical cravings tend to subside within a few weeks, the mental and emotional effects associated with nicotine withdrawal may last months, and you may need some help from your doctor to get through these, particularly if you have a history of anxiety or depression

Risk factors for oral cancer in newly diagnosed patients aged 45 years and younger: a casecontrol study in southern England

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Unlike cigarettes, however, most people who use smokeless tobacco keep it in their mouth for thirty minutes or more at a time