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Although we began to understand in the 1930s (when lung cancer cases dramatically increased among veterans who had started smoking in World War I) that it takes 15 to 20 years for lung cancer to develop, with non-combustible tobacco products there isnt going to be a similar spike in this disease as the 20-year mark approaches

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The typical weight likely falls more closely between 2.5 and 3.5 grams (see Appendix F)

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We applied Gene Set Variation Analysis (GSVA) and Gene Set Enrichment Analysis (GSEA) to evaluate the changes in various gene sets among the different groups