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The DNA regulatory sequence accountable for stimulation by indirect antioxidant pathway inducers was identified as an antioxidant response element (ARE), while Nrf2 was subsequently recognized as the xenobiotic-activated receptor (XAR) major regulator responsible for the activation of ARE-dependent drug metabolizing enzymes [39]

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It was this discovery that led to the filing of more than 1,000 criminal charges, ranging from contraband introduction to drug trafficking and felons in possession of firearms